A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy
Identifieur interne : 000846 ( Main/Exploration ); précédent : 000845; suivant : 000847A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy
Auteurs : Adewale O. Oladipo [Afrique du Sud] ; Oluwatobi S. Oluwafemi [Afrique du Sud] ; Sandile P. Songca [Afrique du Sud] ; Ariunbuyan Sukhbaatar [Japon] ; Shiro Mori [Japon] ; Junnosuke Okajima [Japon] ; Atsuki Komiya [Japon] ; Shigenao Maruyama [Japon] ; Tetsuya Kodama [Japon]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first time that polymeric gold nanorods (PAuNRs) can be delivered efficiently from an accessory axillary lymph node to a tumor-containing proper axillary lymph node, enabling effective treatment of lymph node metastasis. In a mouse model of metastasis, lymphatic spread of tumor was inhibited by lymphatic-delivered PAuNRs and near-infrared laser irradiation, with the skin temperature controlled by cooling. Unlike intravenous injection, lymphatic injection delivered PAuNRs at a high concentration within a short period. The results show that lymphatic administration has the potential to deliver anti-cancer agents to metastatic lymph nodes for inhibition of tumor growth and could be developed into a new therapeutic method.
Url:
DOI: 10.1038/srep45459
PubMed: 28368042
PubMed Central: 5377366
Affiliations:
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Oladipo</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Applied Chemistry, University of Johannesburg</institution>, P.O. Box 17011, Doornfontein 2028, Johannesburg,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Centre for Nanomaterials Science Research, University of Johannesburg</institution>, P.O. Box 17011, Doornfontein 2028, Johannesburg,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oluwafemi, Oluwatobi S" sort="Oluwafemi, Oluwatobi S" uniqKey="Oluwafemi O" first="Oluwatobi S." last="Oluwafemi">Oluwatobi S. Oluwafemi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Applied Chemistry, University of Johannesburg</institution>, P.O. Box 17011, Doornfontein 2028, Johannesburg,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Centre for Nanomaterials Science Research, University of Johannesburg</institution>, P.O. Box 17011, Doornfontein 2028, Johannesburg,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Songca, Sandile P" sort="Songca, Sandile P" uniqKey="Songca S" first="Sandile P." last="Songca">Sandile P. Songca</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Chemistry, University of Zululand</institution>, PB X1001, KwaDlangezwa, 3886,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sukhbaatar, Ariunbuyan" sort="Sukhbaatar, Ariunbuyan" uniqKey="Sukhbaatar A" first="Ariunbuyan" last="Sukhbaatar">Ariunbuyan Sukhbaatar</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Oral and Maxillofacial Surgery, Tohoku University Hospital</institution>, 1-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Okajima, Junnosuke" sort="Okajima, Junnosuke" uniqKey="Okajima J" first="Junnosuke" last="Okajima">Junnosuke Okajima</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Institute of Fluid Science, Tohoku University</institution>, 2-1-1 Katahira, Aoba Ward, Sendai, Miyagi 980-8577,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Komiya, Atsuki" sort="Komiya, Atsuki" uniqKey="Komiya A" first="Atsuki" last="Komiya">Atsuki Komiya</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Institute of Fluid Science, Tohoku University</institution>, 2-1-1 Katahira, Aoba Ward, Sendai, Miyagi 980-8577,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maruyama, Shigenao" sort="Maruyama, Shigenao" uniqKey="Maruyama S" first="Shigenao" last="Maruyama">Shigenao Maruyama</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Institute of Fluid Science, Tohoku University</institution>, 2-1-1 Katahira, Aoba Ward, Sendai, Miyagi 980-8577,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kodama, Tetsuya" sort="Kodama, Tetsuya" uniqKey="Kodama T" first="Tetsuya" last="Kodama">Tetsuya Kodama</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first time that polymeric gold nanorods (PAuNRs) can be delivered efficiently from an accessory axillary lymph node to a tumor-containing proper axillary lymph node, enabling effective treatment of lymph node metastasis. In a mouse model of metastasis, lymphatic spread of tumor was inhibited by lymphatic-delivered PAuNRs and near-infrared laser irradiation, with the skin temperature controlled by cooling. Unlike intravenous injection, lymphatic injection delivered PAuNRs at a high concentration within a short period. The results show that lymphatic administration has the potential to deliver anti-cancer agents to metastatic lymph nodes for inhibition of tumor growth and could be developed into a new therapeutic method.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chandrasekaran, S" uniqKey="Chandrasekaran S">S. Chandrasekaran</name></author><author><name sortKey="Chan, M F" uniqKey="Chan M">M. F. Chan</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="King, M R" uniqKey="King M">M. R. King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shirai, Y" uniqKey="Shirai Y">Y. Shirai</name></author><author><name sortKey="Wakai, T" uniqKey="Wakai T">T. Wakai</name></author><author><name sortKey="Hatakeyama, K" uniqKey="Hatakeyama K">K. 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Mori</name></author><author><name sortKey="Kodama, T" uniqKey="Kodama T">T. Kodama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kodama, T" uniqKey="Kodama T">T. Kodama</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Japon</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Oladipo, Adewale O" sort="Oladipo, Adewale O" uniqKey="Oladipo A" first="Adewale O." last="Oladipo">Adewale O. Oladipo</name></noRegion><name sortKey="Oladipo, Adewale O" sort="Oladipo, Adewale O" uniqKey="Oladipo A" first="Adewale O." last="Oladipo">Adewale O. Oladipo</name><name sortKey="Oluwafemi, Oluwatobi S" sort="Oluwafemi, Oluwatobi S" uniqKey="Oluwafemi O" first="Oluwatobi S." last="Oluwafemi">Oluwatobi S. Oluwafemi</name><name sortKey="Oluwafemi, Oluwatobi S" sort="Oluwafemi, Oluwatobi S" uniqKey="Oluwafemi O" first="Oluwatobi S." last="Oluwafemi">Oluwatobi S. Oluwafemi</name><name sortKey="Songca, Sandile P" sort="Songca, Sandile P" uniqKey="Songca S" first="Sandile P." last="Songca">Sandile P. Songca</name></country><country name="Japon"><noRegion><name sortKey="Sukhbaatar, Ariunbuyan" sort="Sukhbaatar, Ariunbuyan" uniqKey="Sukhbaatar A" first="Ariunbuyan" last="Sukhbaatar">Ariunbuyan Sukhbaatar</name></noRegion><name sortKey="Kodama, Tetsuya" sort="Kodama, Tetsuya" uniqKey="Kodama T" first="Tetsuya" last="Kodama">Tetsuya Kodama</name><name sortKey="Kodama, Tetsuya" sort="Kodama, Tetsuya" uniqKey="Kodama T" first="Tetsuya" last="Kodama">Tetsuya Kodama</name><name sortKey="Komiya, Atsuki" sort="Komiya, Atsuki" uniqKey="Komiya A" first="Atsuki" last="Komiya">Atsuki Komiya</name><name sortKey="Maruyama, Shigenao" sort="Maruyama, Shigenao" uniqKey="Maruyama S" first="Shigenao" last="Maruyama">Shigenao Maruyama</name><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name><name sortKey="Okajima, Junnosuke" sort="Okajima, Junnosuke" uniqKey="Okajima J" first="Junnosuke" last="Okajima">Junnosuke Okajima</name><name sortKey="Sukhbaatar, Ariunbuyan" sort="Sukhbaatar, Ariunbuyan" uniqKey="Sukhbaatar A" first="Ariunbuyan" last="Sukhbaatar">Ariunbuyan Sukhbaatar</name><name sortKey="Sukhbaatar, Ariunbuyan" sort="Sukhbaatar, Ariunbuyan" uniqKey="Sukhbaatar A" first="Ariunbuyan" last="Sukhbaatar">Ariunbuyan Sukhbaatar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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